Endocrine Abstracts

A 58-year-old female presented with a 20-year history of resistant hypertension and hypokalaemia, with normal renal function. Investigations confirmed primary hyperaldosteronism that was not suppressed following a standard saline infusion test. CT scanning revealed a right-sided adrenal mass of 1.3 cm, with a signal intensity of −1 HU. The left adrenal was normal in appearance. A LDDST excluded ACTH-independent Cushing’s syndrome. Adrenal vein sampling confirmed rig...

In type 1 diabetes mellitus, tight glycaemic control is required to attenuate chronic complications and often requires daily injectable insulin therapy, which can result in non-compliance because of patient discomfort. As a result of this, some studies are concerned with optional routes of insulin administration. In our laboratory, we have developed amidated pectin (polygalacturonic acid) hydrogel beads for oral insulin administration. The aim of present was to investigate whe...

Hypoparathyroidism is a disorder of mineral homoeostasis due to parathyroid hormone (PTH) deficiency. Conventional treatment with oral Ca and calcitriol may maintain serum Ca levels but does not replace other physiologic PTH effects. RACE is an ongoing open-label study of recombinant human PTH1-84 (rhPTH1-84) for hypoparathyroidism treatment in adults (ClinicalTrials.gov NCT01297309). Patients initially received rhPTH1-84 25 or 50 μg/day subcutaneously, with 25-μg in...

High protein diets are highly satiating but hard to maintain. By understanding the mechanisms underlying these effects we may be able to identify new anti-obesity therapies. Protein is broken-down into amino acids in the gut which are detected by a series of nutrient sensors. The calcium sensing receptor (CaSR) is primarily activated by calcium ions, but is positively allosterically modulated by aromatic amino acids, especially L-phenylalanine. Sti...

High protein diets are highly satiating but hard to maintain. By understanding the mechanisms underlying these effects we may be able to identify new anti-obesity therapies. Protein is broken-down into amino acids in the gut which are detected by a series of nutrient sensors. The calcium sensing receptor (CaSR) is primarily activated by calcium ions, but is positively allosterically modulated by aromatic amino acids, especially L-phenylalanine. Sti...

Background: Despite relevant evidence that the absorption and/or action of L-thyroxine is compromised by various factors including the diet, until 2014 the British National Formula (BNF) recommended that L-thyroxine be taken ‘preferably before breakfast’ only, with no further clarifications. To follow is one of the cases where untimely food intake in hypothyroid patients manifested with severe hypothyroidism due to L-thyro...

Background: RACE is an open-label study that assessed the long-term safety and efficacy of recombinant human parathyroid hormone 1–84 (rhPTH[1–84]) for the treatment of hypoparathyroidism in adults (ClinicalTrials.gov identifier NCT01297309). Here, we present 6-year safety and efficacy data.Methods: Patients initially received 25 or 50 μg of rhPTH(1–84) subcutaneously, once daily, with stepwise dose adjustments of 25 μg (up or do...

High protein diets suppress appetite, but are difficult to adhere to. Understanding how the gut senses protein may identify mechanisms to drive satiety. Amino acid products of protein digestion are thought to be sensed by G protein coupled receptors in the gut, including the calcium sensing receptor (CaSR). Calcium ions are the major ligand of the CaSR, but aromatic amino acids, particularly L-phenylalanine (L-Phe), allosterically modulate CaSR activity....

Introduction: Neutrophil/lymphocyte (N/L) ratio is considered as a sign of systemic inflammation in recent years. In our study, we aimed to investigate N/L ratio in hyperthyroid patients and healthy control group.Material & methods: A total of 121 hyperthyroid patients (71 patients with Graves’ disease and 50 patients with other causes of hyperthyroidism) and 40 healthy volunteers were enrolled. Complete blood count was obtained from both group ...

Objective: To demonstrate the effectiveness and compliance to L-thyroxine in the treatment of hypothyroidism in a weekly dose of seven times of normal dose as an alternative to daily dosing in young and middle aged females.Methods: Randomized trial on 40 female patients aged between 25 to 55 years with long standing hypothyroidism of 5 years or more, currently on daily dose of L-thyroxine, were assigned weekly dose of seven ...